FAIRMol

KB_Leish_41

Pose ID 42571 Compound 702 Pose 484

DB Docking_panel_21Docking pose analysis is being read from this database.
Molecular metrics status: queued
Pose metrics recompute is queued in the background.
Metrics cached · SASA missing
T18
Trypanothione reductase (TryR / TR) Trypanosoma brucei
Ligand KB_Leish_41
PDB6RB5

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Weak No SASA yet
Promising but geometrically suspicious
Binding strong Geometry low Native strong SASA missing
Strain ΔE
46.0 kcal/mol
Protein clashes
0
Internal clashes
13
Native overlap
contact recall 0.69, Jaccard 0.53
Burial
87%
Reason: 13 internal clashes, strain 46.0 kcal/mol
strain ΔE 46.0 kcal/mol 13 intramolecular clashes

Interaction summary

HB 4 HY 21 PI 2 CLASH 0
Final rank7.659Score-18.694
Inter norm-0.628Intra norm0.044
Top1000noExcludedyes
Contacts13H-bonds2
Artifact reasonexcluded; geometry warning; 13 clashes; 1 protein clash; high strain Δ 46.0
Residues
ASP105 ASP116 GLU18 GLY112 ILE339 LEU17 LYS108 MET113 SER109 SER14 THR117 TRP21 TYR110

Protein summary

493 residues
Protein targetT18Atoms7550
Residues493Chains1
Residue summaryVAL:768; LYS:704; LEU:703; ILE:532; GLU:450; THR:434; ARG:408; PHE:400; ALA:390; ASN:350; PRO:350; GLY:336; SER:319; TYR:294; ASP:276; MET:221

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
A:FAD501

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: permissive.
Name6RB5Contacts13
PoseOpen native poseHB0
IFP residues
ASP116 GLU18 GLY112 ILE106 LEU17 MET113 SER109 THR117 THR335 TRP21 TYR110 VAL53 VAL58
Current overlap9Native recall0.69
Jaccard0.53RMSD-
HB strict0Strict recall-
HB same residue+role0HB role recall-
HB same residue0HB residue recall-

HB · H-bonds

Mode: permissive. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

Native π–π recall is disabled because no explicit native π–π reference was stored.

HY · Hydrophobic contacts

CLASH · Clashes

No clash · clashes detected for this pose.

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
491 4.918248685407759 -0.937426 -26.6984 5 21 0 0.00 - - no Open
595 5.575090899916919 -0.7408 -24.8635 4 18 0 0.00 - - no Open
414 6.434035714449353 -0.717975 -25.5926 4 13 0 0.00 - - no Open
485 6.500526567711173 -0.675873 -24.2658 4 13 7 0.54 - - no Open
530 6.605912727722192 -0.809895 -27.4202 5 20 0 0.00 - - no Open
484 7.658521530819854 -0.628344 -18.6935 2 13 9 0.69 - - yes Current
529 8.323509071516625 -0.964933 -23.9292 7 20 0 0.00 - - yes Open
490 8.55090867045927 -0.776061 -19.809 3 19 0 0.00 - - yes Open
594 10.819536765416256 -0.842022 -25.106 5 19 0 0.00 - - yes Open

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.