FAIRMol

KB_HAT_92

Pose ID 47470 Compound 1835 Pose 505

DB Docking_panel_21Docking pose analysis is being read from this database.
Molecular metrics status: queued
Pose metrics recompute is queued in the background.
Metrics cached · SASA missing
T20
Trypanothione reductase (TryR / TR) Trypanosoma brucei
Ligand KB_HAT_92
PDB9IFH

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Reject No SASA yet
Likely artefact or unreliable pose
Binding strong Geometry medium Native strong SASA missing
Strain ΔE
25.0 kcal/mol
Protein clashes
3
Internal clashes
3
Native overlap
contact recall 0.75, Jaccard 0.43, H-bond role recall 0.00
Burial
100%
Reason: no major geometry red flags detected
3 protein-contact clashes 3 intramolecular clashes

Interaction summary

HB 4 HY 18 PI 1 CLASH 3
Final rank5.138Score-17.243
Inter norm-0.517Intra norm-0.005
Top1000noExcludedno
Contacts12H-bonds3
Artifact reasongeometry warning; 16 clashes; 5 protein contact clashes; high strain Δ 25.0
Residues
ASN402 GLU466 GLU467 HIS461 LEU399 MET400 PHE396 PRO398 PRO462 SER464 THR397 THR463

Protein summary

492 residues
Protein targetT20Atoms7539
Residues492Chains1
Residue summaryVAL:768; LYS:704; LEU:703; ILE:532; GLU:450; THR:434; ARG:408; PHE:400; ALA:390; ASN:350; PRO:350; GLY:336; SER:319; TYR:294; ASP:264; MET:221

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
A:FAD501

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: permissive.
Name9IFHContacts8
PoseOpen native poseHB0
IFP residues
ASN402 GLU467 LEU399 PHE396 PRO398 SER394 SER470 THR397
Current overlap6Native recall0.75
Jaccard0.43RMSD-
HB strict0Strict recall0.00
HB same residue+role0HB role recall0.00
HB same residue0HB residue recall0.00

HB · H-bonds

Mode: permissive. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

Native π–π recall is disabled because no explicit native π–π reference was stored.

HY · Hydrophobic contacts

CLASH · Clashes

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
371 3.4586492485698055 -0.675252 -23.2922 0 17 0 0.00 0.00 - no Open
378 3.496030626412555 -0.675807 -23.4281 2 16 0 0.00 0.00 - no Open
374 3.9250438716541782 -0.695403 -24.2155 1 17 0 0.00 0.00 - no Open
512 4.2979278576833835 -0.49497 -15.8886 4 11 8 1.00 0.00 - no Open
511 4.471628861856435 -0.50766 -17.1565 2 16 6 0.75 0.00 - no Open
519 4.589960709862747 -0.52454 -16.0228 3 13 6 0.75 1.00 - no Open
523 4.606530609640901 -0.501908 -16.7466 3 10 7 0.88 0.00 - no Open
385 4.758016192794349 -0.697872 -23.1599 3 19 0 0.00 0.00 - no Open
382 4.763352933556748 -0.708228 -22.2989 2 16 0 0.00 0.00 - no Open
388 4.914031533037135 -0.646828 -22.5838 0 18 0 0.00 0.00 - no Open
505 5.138498388653485 -0.51736 -17.2433 3 12 6 0.75 0.00 - no Current
515 5.3051199626714105 -0.539572 -15.9096 6 12 6 0.75 0.00 - no Open
525 5.413941586743036 -0.48055 -12.5753 4 12 5 0.62 0.00 - no Open
380 5.8722584504483475 -0.705871 -22.5087 4 19 0 0.00 0.00 - no Open
391 5.971169185066075 -0.761434 -26.5476 2 20 0 0.00 0.00 - no Open
521 5.983928639378474 -0.511809 -17.0502 5 10 6 0.75 0.00 - no Open
508 6.196022996676622 -0.582134 -13.7699 3 14 4 0.50 1.00 - no Open
376 54.47629260896436 -0.682666 -22.8735 0 18 0 0.00 0.00 - no Open
373 54.7346984520923 -0.67366 -24.3006 3 19 0 0.00 0.00 - no Open
504 54.851468960085555 -0.56229 -18.1965 6 12 6 0.75 0.00 - no Open
527 55.408942935001576 -0.524715 -15.5822 2 11 8 1.00 0.00 - no Open
522 55.47754696006758 -0.607498 -20.2131 3 11 5 0.62 0.00 - no Open
390 8.198709249155613 -0.723969 -24.3227 3 16 0 0.00 0.00 - yes Open
506 54.51397240637387 -0.590165 -19.6465 2 13 6 0.75 0.00 - yes Open
520 55.04143451972142 -0.508874 -13.7804 3 15 6 0.75 1.00 - yes Open
375 55.09288791589591 -0.662319 -18.3103 0 15 0 0.00 0.00 - yes Open
384 55.38328390617979 -0.724293 -23.476 2 16 0 0.00 0.00 - yes Open
507 55.62993479624877 -0.532499 -18.0133 2 12 8 1.00 0.00 - yes Open
379 55.69395775887694 -0.576556 -17.7433 1 14 0 0.00 0.00 - yes Open
381 56.19589585651691 -0.73696 -23.2743 2 16 0 0.00 0.00 - yes Open
518 56.3288826690683 -0.541973 -18.0544 3 12 6 0.75 0.00 - yes Open
524 56.51635105432311 -0.518813 -17.2549 2 13 7 0.88 0.00 - yes Open
517 56.53315887202536 -0.577547 -18.1703 4 12 6 0.75 1.00 - yes Open
516 56.54714676274892 -0.62692 -20.7114 5 14 6 0.75 1.00 - yes Open
526 56.756179931641555 -0.577226 -20.8001 2 12 6 0.75 0.00 - yes Open
513 56.760234199634965 -0.580808 -19.0458 3 12 6 0.75 0.00 - yes Open
510 56.93084813508818 -0.528899 -19.2234 1 11 6 0.75 0.00 - yes Open
372 56.941507731286165 -0.733992 -25.6449 5 18 0 0.00 0.00 - yes Open
514 57.0514878410568 -0.536058 -12.4352 4 9 7 0.88 0.00 - yes Open
509 57.343463313127764 -0.550259 -16.9338 4 9 7 0.88 1.00 - yes Open
389 57.53268575769582 -0.724842 -24.4981 3 17 0 0.00 0.00 - yes Open
387 57.60153556972629 -0.7968 -27.5621 4 19 0 0.00 0.00 - yes Open
386 57.93296225764177 -0.705431 -22.8546 3 19 0 0.00 0.00 - yes Open
392 58.06220477165874 -0.673351 -23.8551 3 13 0 0.00 0.00 - yes Open
377 58.24533449057982 -0.730363 -24.9655 2 17 0 0.00 0.00 - yes Open
394 58.413540509503925 -0.641178 -19.7011 3 14 0 0.00 0.00 - yes Open
383 58.56718905928218 -0.678505 -21.0382 2 14 0 0.00 0.00 - yes Open
393 58.80610830853585 -0.664156 -23.0193 2 16 0 0.00 0.00 - yes Open

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.