FAIRMol

Z28139319

Pose ID 46842 Compound 3257 Pose 2109

DB Docking_panel_21Docking pose analysis is being read from this database.
Molecular metrics status: queued
Pose metrics recompute is queued in the background.
Metrics cached · SASA missing
T19
Trypanothione reductase (TryR / TR) Trypanosoma brucei
Ligand Z28139319
PDB2WOV

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Weak No SASA yet
Weak or marginal quality
Binding strong Geometry medium Native mixed SASA missing
Strain ΔE
not computed
Protein clashes
8
Internal clashes
1
Native overlap
contact recall 0.30, Jaccard 0.20, H-bond role recall 0.20
Burial
100%
Reason: no major geometry red flags detected
8 protein-contact clashes

Interaction summary

HB 8 HY 24 PI 2 CLASH 1
Final rank4.785Score-29.739
Inter norm-1.035Intra norm0.010
Top1000noExcludedno
Contacts22H-bonds3
Artifact reasongeometry warning; 16 clashes; 8 protein contact clashes
Residues
ALA338 ALA365 ASP327 CYS52 CYS57 GLU202 GLY56 ILE199 LEU334 LYS60 MET333 NDP800 PHE182 PHE203 PHE367 PRO336 SER14 SER178 SER364 THR335 THR51 VAL55

Protein summary

493 residues
Protein targetT19Atoms7541
Residues493Chains1
Residue summaryVAL:768; LYS:704; LEU:703; ILE:532; GLU:450; THR:434; ARG:408; PHE:400; ALA:390; ASN:350; PRO:350; GLY:336; SER:330; TYR:294; ASP:264; MET:221

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
C:NDP800

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: permissive.
Name2WOVContacts27
PoseOpen native poseHB0
IFP residues
ALA284 ALA365 ARG222 ARG228 ARG287 ASN223 ASN254 GLN165 GLU202 GLY195 GLY196 GLY197 GLY286 ILE199 ILE285 LEU227 LEU334 LYS60 MET333 NDP800 PHE198 PHE367 PRO167 SER200 TYR221 VAL194 VAL366
Current overlap8Native recall0.30
Jaccard0.20RMSD-
HB strict1Strict recall0.08
HB same residue+role1HB role recall0.20
HB same residue1HB residue recall0.25

HB · H-bonds

Mode: permissive. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

Native π–π recall is disabled because no explicit native π–π reference was stored.

HY · Hydrophobic contacts

CLASH · Clashes

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
2109 4.78494693647827 -1.03502 -29.739 3 22 8 0.30 0.20 - no Current

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.