FAIRMol

Z31287535

Pose ID 37999 Compound 3060 Pose 3358

DB Docking_panel_21Docking pose analysis is being read from this database.
Molecular metrics status: queued
Pose metrics recompute is queued in the background.
Metrics cached · SASA missing
T16
Trypanothione reductase (TryR / TR) Trypanosoma brucei
Ligand Z31287535
PDB6RB5

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Weak No SASA yet
Weak or marginal quality
Binding strong Geometry medium Native mixed SASA missing
Strain ΔE
38.5 kcal/mol
Protein clashes
2
Internal clashes
2
Native overlap
contact recall 0.50, Jaccard 0.30
Burial
96%
Reason: no major geometry red flags detected
2 protein-contact clashes

Interaction summary

HB 3 HY 17 PI 0 CLASH 2
Final rank9.377Score-17.780
Inter norm-0.589Intra norm0.095
Top1000noExcludedyes
Contacts14H-bonds3
Artifact reasonexcluded; geometry warning; 19 clashes; 1 protein clash; high strain Δ 38.5
Residues
ALA90 ASN91 GLY214 GLY215 LYS211 LYS89 LYS93 PRO187 PRO212 PRO213 SER86 TRP92 TYR210 VAL88

Protein summary

493 residues
Protein targetT16Atoms7551
Residues493Chains1
Residue summaryVAL:768; LYS:704; LEU:703; ILE:532; GLU:450; THR:434; ARG:408; PHE:400; ALA:390; ASN:350; PRO:350; GLY:336; SER:319; TYR:294; ASP:276; MET:221

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
A:FAD501

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: permissive.
Name6RB5Contacts12
PoseOpen native poseHB0
IFP residues
ALA90 ARG74 GLY85 LEU73 LYS89 MET70 PHE83 PRO212 PRO213 SER86 SER87 VAL88
Current overlap6Native recall0.50
Jaccard0.30RMSD-
HB strict0Strict recall-
HB same residue+role0HB role recall-
HB same residue0HB residue recall-

HB · H-bonds

Mode: permissive. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

No pi · π–π interactions detected for this pose.

HY · Hydrophobic contacts

CLASH · Clashes

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
3363 8.305222480009716 -0.553149 -16.4904 4 14 9 0.75 - - no Open
3355 9.312999714189637 -0.549556 -18.6202 5 11 5 0.42 - - no Open
3361 9.45087329036194 -0.56248 -19.2504 5 14 7 0.58 - - no Open
3358 9.376741250522832 -0.588934 -17.7802 3 14 6 0.50 - - yes Current
3359 9.871561380476695 -0.570653 -14.3159 6 15 8 0.67 - - yes Open
3357 11.427609731269518 -0.694549 -23.6471 5 14 6 0.50 - - yes Open
3360 11.465454633247798 -0.579075 -12.4481 3 16 11 0.92 - - yes Open
3364 11.478744195366229 -0.637698 -20.2452 6 18 10 0.83 - - yes Open
3362 60.915756674225335 -0.531004 -16.2875 2 15 9 0.75 - - yes Open
3356 62.44255858387012 -0.621838 -21.3269 5 15 8 0.67 - - yes Open

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.