FAIRMol

KB_HAT_92

Pose ID 15590 Compound 1835 Pose 393

DB Docking_panel_21Docking pose analysis is being read from this database.
Molecular metrics status: queued
Pose metrics recompute is queued in the background.
Metrics cached · SASA missing
T09
Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) likely Leishmania major / Leishmania sp. homology model
Ligand KB_HAT_92
PDB3CL9-template

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Weak No SASA yet
Weak or marginal quality
Binding strong Geometry medium Native strong SASA missing
Strain ΔE
not computed
Protein clashes
3
Internal clashes
3
Native overlap
contact recall 0.67, Jaccard 0.61, H-bond role recall 0.17
Burial
96%
Reason: no major geometry red flags detected
3 protein-contact clashes 3 intramolecular clashes

Interaction summary

HB 2 HY 24 PI 2 CLASH 3
Final rank58.806Score-23.019
Inter norm-0.664Intra norm-0.033
Top1000noExcludedyes
Contacts16H-bonds2
Artifact reasonexcluded; geometry warning; 18 clashes; 1 protein clash
Residues
NDP301 ALA32 ARG97 ASP52 ILE45 LEU94 LYS57 LYS95 MET53 PHE56 PHE91 PRO88 PRO93 VAL156 VAL30 VAL87

Protein summary

511 residues
Protein targetT09Atoms8170
Residues511Chains2
Residue summaryLEU:1064; ARG:840; LYS:572; GLU:570; VAL:528; PHE:460; ILE:456; ALA:440; PRO:420; THR:406; TYR:357; ASP:312; GLN:289; ASN:238; SER:231; GLY:224

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
A:NDP301

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: strict.
Name3CL9Contacts21
PoseOpen native poseHB0
IFP residues
NDP301 ALA32 ARG97 ASP52 GLY157 ILE45 LEU94 LYS57 MET53 PHE55 PHE56 PHE91 PRO88 SER86 THR180 THR83 TYR162 VAL156 VAL30 VAL31 VAL87
Current overlap14Native recall0.67
Jaccard0.61RMSD-
HB strict2Strict recall0.29
HB same residue+role1HB role recall0.17
HB same residue1HB residue recall0.17

HB · H-bonds

Mode: strict. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

Native π–π recall is disabled because no explicit native π–π reference was stored.

HY · Hydrophobic contacts

CLASH · Clashes

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
371 3.4586492485698055 -0.675252 -23.2922 0 17 16 0.76 0.00 - no Open
378 3.496030626412555 -0.675807 -23.4281 2 16 15 0.71 0.17 - no Open
374 3.9250438716541782 -0.695403 -24.2155 1 17 16 0.76 0.17 - no Open
512 4.2979278576833835 -0.49497 -15.8886 4 11 0 0.00 0.00 - no Open
511 4.471628861856435 -0.50766 -17.1565 2 16 0 0.00 0.00 - no Open
519 4.589960709862747 -0.52454 -16.0228 3 13 0 0.00 0.00 - no Open
523 4.606530609640901 -0.501908 -16.7466 3 10 0 0.00 0.00 - no Open
385 4.758016192794349 -0.697872 -23.1599 3 19 14 0.67 0.17 - no Open
382 4.763352933556748 -0.708228 -22.2989 2 16 15 0.71 0.17 - no Open
388 4.914031533037135 -0.646828 -22.5838 0 18 14 0.67 0.00 - no Open
505 5.138498388653485 -0.51736 -17.2433 3 12 0 0.00 0.00 - no Open
515 5.3051199626714105 -0.539572 -15.9096 6 12 0 0.00 0.00 - no Open
525 5.413941586743036 -0.48055 -12.5753 4 12 0 0.00 0.00 - no Open
380 5.8722584504483475 -0.705871 -22.5087 4 19 14 0.67 0.17 - no Open
391 5.971169185066075 -0.761434 -26.5476 2 20 16 0.76 0.00 - no Open
521 5.983928639378474 -0.511809 -17.0502 5 10 0 0.00 0.00 - no Open
508 6.196022996676622 -0.582134 -13.7699 3 14 0 0.00 0.00 - no Open
376 54.47629260896436 -0.682666 -22.8735 0 18 16 0.76 0.00 - no Open
373 54.7346984520923 -0.67366 -24.3006 3 19 16 0.76 0.17 - no Open
504 54.851468960085555 -0.56229 -18.1965 6 12 0 0.00 0.00 - no Open
527 55.408942935001576 -0.524715 -15.5822 2 11 0 0.00 0.00 - no Open
522 55.47754696006758 -0.607498 -20.2131 3 11 0 0.00 0.00 - no Open
390 8.198709249155613 -0.723969 -24.3227 3 16 15 0.71 0.17 - yes Open
506 54.51397240637387 -0.590165 -19.6465 2 13 0 0.00 0.00 - yes Open
520 55.04143451972142 -0.508874 -13.7804 3 15 0 0.00 0.00 - yes Open
375 55.09288791589591 -0.662319 -18.3103 0 15 15 0.71 0.00 - yes Open
384 55.38328390617979 -0.724293 -23.476 2 16 15 0.71 0.17 - yes Open
507 55.62993479624877 -0.532499 -18.0133 2 12 0 0.00 0.00 - yes Open
379 55.69395775887694 -0.576556 -17.7433 1 14 11 0.52 0.17 - yes Open
381 56.19589585651691 -0.73696 -23.2743 2 16 15 0.71 0.17 - yes Open
518 56.3288826690683 -0.541973 -18.0544 3 12 0 0.00 0.00 - yes Open
524 56.51635105432311 -0.518813 -17.2549 2 13 0 0.00 0.00 - yes Open
517 56.53315887202536 -0.577547 -18.1703 4 12 0 0.00 0.00 - yes Open
516 56.54714676274892 -0.62692 -20.7114 5 14 0 0.00 0.00 - yes Open
526 56.756179931641555 -0.577226 -20.8001 2 12 0 0.00 0.00 - yes Open
513 56.760234199634965 -0.580808 -19.0458 3 12 0 0.00 0.00 - yes Open
510 56.93084813508818 -0.528899 -19.2234 1 11 0 0.00 0.00 - yes Open
372 56.941507731286165 -0.733992 -25.6449 5 18 14 0.67 0.17 - yes Open
514 57.0514878410568 -0.536058 -12.4352 4 9 0 0.00 0.00 - yes Open
509 57.343463313127764 -0.550259 -16.9338 4 9 0 0.00 0.00 - yes Open
389 57.53268575769582 -0.724842 -24.4981 3 17 16 0.76 0.17 - yes Open
387 57.60153556972629 -0.7968 -27.5621 4 19 15 0.71 0.00 - yes Open
386 57.93296225764177 -0.705431 -22.8546 3 19 16 0.76 0.00 - yes Open
392 58.06220477165874 -0.673351 -23.8551 3 13 7 0.33 0.00 - yes Open
377 58.24533449057982 -0.730363 -24.9655 2 17 15 0.71 0.17 - yes Open
394 58.413540509503925 -0.641178 -19.7011 3 14 8 0.38 0.00 - yes Open
383 58.56718905928218 -0.678505 -21.0382 2 14 10 0.48 0.17 - yes Open
393 58.80610830853585 -0.664156 -23.0193 2 16 14 0.67 0.17 - yes Current

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.