FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02
ulfkktlib_697
[H]N(C(=O)c1ccccc1)[C@@H]1C(=O)N([H])/[N+](=C\C2=CC[C@H]3C[C@]2(C)[C@@H]3C)[C@H]1c1ccccc1
0.796 0.796 2 0.80 0.80

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
ulfkktlib_697
[H]N(C(=O)c1ccccc1)[C@@H]1C(=O)N([H])/[N+](=C\C2=CC[C@H]3C[C@]2(C)[C@@H]3C)[C@H]1c1ccccc1
T01
native IFP available
T01
selection_import_t01
0.796 1.000 0.416 native_similarity final_rank_score -24.4239 -0.865644 17 3 Pose
ulfkktlib_697
[H]N(C(=O)c1ccccc1)[C@@H]1C(=O)N([H])/[N+](=C\C2=CC[C@H]3C[C@]2(C)[C@@H]3C)[C@H]1c1ccccc1
T02
native IFP available
T02
selection_import_t02
0.796 1.000 0.416 native_similarity final_rank_score -24.5332 -0.86018 17 3 Pose