FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 6 best compound-target hits listed 6 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T06T11T12T20T22
Z73416904 0.914 0.838 6 0.78 0.80 0.91 0.90 0.79 0.84

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z73416904 T11
native IFP available
T11
selection_import_t11
0.914 1.000 0.753 native_similarity final_rank_score -28.0656 -0.901399 15 4 Pose
Z73416904 T12
native IFP available
T12
selection_import_t12
0.905 1.000 0.727 native_similarity final_rank_score -29.7352 -0.923116 16 11 Pose
Z73416904 T22
native IFP available
T22
selection_import_t22
0.836 1.000 0.530 native_similarity final_rank_score -31.4245 -1.03651 23 13 Pose
Z73416904 T06
native IFP available
T06
selection_import_t06
0.802 1.000 0.433 native_similarity final_rank_score -21.8571 -0.743905 17 2 Pose
Z73416904 T20
native IFP available
T20
selection_import_t20
0.793 1.000 0.410 native_similarity final_rank_score -20.0918 -0.679833 11 4 Pose
Z73416904 T03
native IFP available
T03
selection_import_t03
0.780 1.000 0.370 native_similarity final_rank_score -27.1056 -0.876746 15 4 Pose