FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 15 best compound-target hits listed 15 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T04T06T07T08T09T10T11T14T15T17T18T19T21T22
Z68347496 0.951 0.845 13 0.75 0.90 0.91 0.91 0.83 0.89 0.82 0.77 0.77 0.77 0.80 0.95 0.92
Z68347496 0.929 0.888 2 0.85 0.93

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z68347496 T21
native IFP available
T21
selection_import_t21
0.951 1.000 0.860 native_similarity final_rank_score -28.5624 -0.901 17 12 Pose
Z68347496 T10
native IFP available
T10
selection_import_t10
0.929 1.000 0.798 native_similarity final_rank_score -23.3554 -0.843929 16 14 Pose
Z68347496 T22
native IFP available
T22
selection_import_t22
0.925 1.000 0.784 native_similarity final_rank_score -35.1918 -1.36608 19 12 Pose
Z68347496 T07
native IFP available
T07
selection_import_t07
0.908 1.000 0.738 native_similarity final_rank_score -43.7879 -1.38782 19 9 Pose
Z68347496 T08
native IFP available
T08
selection_import_t08
0.908 1.000 0.738 native_similarity final_rank_score -41.1595 -1.32572 19 11 Pose
Z68347496 T06
native IFP available
T06
selection_import_t06
0.900 1.000 0.714 native_similarity final_rank_score -22.4366 -0.846568 19 9 Pose
Z68347496 T11
native IFP available
T11
selection_import_t11
0.893 1.000 0.695 native_similarity final_rank_score -27.1145 -0.866284 17 5 Pose
Z68347496 T04
native IFP available
T04
selection_import_t04
0.847 1.000 0.562 native_similarity final_rank_score -24.1066 -0.884139 12 4 Pose
Z68347496 T09
native IFP available
T09
selection_import_t09
0.827 1.000 0.504 native_similarity final_rank_score -30.1896 -0.86851 19 8 Pose
Z68347496 T14
native IFP available
T14
selection_import_t14
0.818 1.000 0.480 native_similarity final_rank_score -27.284 -0.850102 14 9 Pose
Z68347496 T19
native IFP available
T19
selection_import_t19
0.802 1.000 0.435 native_similarity final_rank_score -34.3256 -1.0689 13 10 Pose
Z68347496 T18
native IFP available
T18
selection_import_t18
0.774 1.000 0.353 native_similarity final_rank_score -24.5919 -0.708586 14 8 Pose
Z68347496 T17
native IFP available
T17
selection_import_t17
0.769 1.000 0.339 native_similarity final_rank_score -23.7085 -0.795751 19 6 Pose
Z68347496 T15
native IFP available
T15
selection_import_t15
0.768 1.000 0.337 native_similarity final_rank_score -27.3268 -0.791858 16 6 Pose
Z68347496 T03
native IFP available
T03
selection_import_t03
0.747 1.000 0.277 native_similarity final_rank_score -21.4571 -0.890481 12 10 Pose