FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T07T10T13T17T22
Z57728545 0.911 0.843 2 0.91 0.78
Z57728545 0.894 0.827 3 0.89 0.86 0.73

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57728545 T10
native IFP available
T10
selection_import_t10
0.911 1.000 0.746 native_similarity final_rank_score -31.9737 -1.24603 18 11 Pose
Z57728545 T07
native IFP available
T07
selection_import_t07
0.894 1.000 0.696 native_similarity final_rank_score -34.383 -1.74729 14 14 Pose
Z57728545 T13
native IFP available
T13
selection_import_t13
0.861 1.000 0.604 native_similarity final_rank_score -29.5873 -1.33631 14 12 Pose
Z57728545 T22
native IFP available
T22
selection_import_t22
0.775 1.000 0.358 native_similarity final_rank_score -27.6741 -1.45275 19 16 Pose
Z57728545 T17
native IFP available
T17
selection_import_t17
0.726 1.000 0.216 native_similarity final_rank_score -26.3826 -1.09287 15 8 Pose