FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T07T12T14
Z57108748 0.856 0.825 3 0.85 0.86 0.77

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57108748 T12
native IFP available
T12
selection_import_t12
0.856 1.000 0.587 native_similarity final_rank_score -24.9999 -1.42954 16 6 Pose
Z57108748 T07
native IFP available
T07
selection_import_t07
0.854 1.000 0.582 native_similarity final_rank_score -30.2969 -1.72071 12 8 Pose
Z57108748 T14
native IFP available
T14
selection_import_t14
0.767 1.000 0.333 native_similarity final_rank_score -21.9216 -1.33148 13 5 Pose