FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T16
Z56842660 0.779 0.767 3 0.78 0.78 0.74

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56842660 T01
native IFP available
T01
selection_import_t01
0.779 1.000 0.370 native_similarity final_rank_score -27.4673 -1.01549 13 4 Pose
Z56842660 T02
native IFP available
T02
selection_import_t02
0.779 1.000 0.370 native_similarity final_rank_score -27.3748 -1.01104 13 4 Pose
Z56842660 T16
native IFP available
T16
selection_import_t16
0.743 1.000 0.264 native_similarity final_rank_score -24.3892 -0.923793 15 5 Pose