FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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3 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T03T11T12
Z56791336 0.918 0.918 1 0.92
Z56791336 0.833 0.830 2 0.83 0.83
Z56791336 0.826 0.826 1 0.83

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56791336 T12
native IFP available
T12
selection_import_t12
0.918 1.000 0.765 native_similarity final_rank_score -34.9559 -0.835046 17 10 Pose
Z56791336 T11
native IFP available
T11
selection_import_t11
0.833 1.000 0.523 native_similarity final_rank_score -32.3329 -0.7484 19 3 Pose
Z56791336 T02
native IFP available
T02
selection_import_t02
0.827 1.000 0.505 native_similarity final_rank_score -24.6598 -0.76085 20 3 Pose
Z56791336 T03
native IFP available
T03
selection_import_t03
0.826 1.000 0.503 native_similarity final_rank_score -23.111 -0.801464 18 2 Pose