FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 10 best compound-target hits listed 10 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T05T09T11T12T15T17T20
Z49605162 0.896 0.843 7 0.81 0.83 0.88 0.82 0.86 0.90 0.80
Z49605162 0.841 0.813 3 0.80 0.80 0.84

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49605162 T12
native IFP available
T12
selection_import_t12
0.896 1.000 0.704 native_similarity final_rank_score -33.8901 -0.799129 16 12 Pose
Z49605162 T05
native IFP available
T05
selection_import_t05
0.877 1.000 0.648 native_similarity final_rank_score -25.697 -0.777932 16 5 Pose
Z49605162 T11
native IFP available
T11
selection_import_t11
0.859 1.000 0.597 native_similarity final_rank_score -29.1396 -0.67053 12 5 Pose
Z49605162 T20
native IFP available
T20
selection_import_t20
0.841 1.000 0.546 native_similarity final_rank_score -20.9526 -0.523319 13 5 Pose
Z49605162 T02
native IFP available
T02
selection_import_t02
0.834 1.000 0.526 native_similarity final_rank_score -24.4136 -0.740293 20 1 Pose
Z49605162 T09
native IFP available
T09
selection_import_t09
0.816 1.000 0.474 native_similarity final_rank_score -27.1423 -0.832732 18 3 Pose
Z49605162 T01
native IFP available
T01
selection_import_t01
0.812 1.000 0.464 native_similarity final_rank_score -28.4085 -0.734944 18 2 Pose
Z49605162 T15
native IFP available
T15
selection_import_t15
0.804 1.000 0.441 native_similarity final_rank_score -26.5396 -0.706763 16 9 Pose
Z49605162 T03
native IFP available
T03
selection_import_t03
0.801 1.000 0.431 native_similarity final_rank_score -21.1329 -0.76133 15 3 Pose
Z49605162 T17
native IFP available
T17
selection_import_t17
0.796 1.000 0.417 native_similarity final_rank_score -26.3408 -0.702863 22 5 Pose