FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 6 best compound-target hits listed 6 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T05T06T07T17T20
Z44591573 0.855 0.799 6 0.78 0.79 0.82 0.85 0.77 0.78

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z44591573 T07
native IFP available
T07
selection_import_t07
0.855 1.000 0.585 native_similarity final_rank_score -26.1104 -1.09358 14 4 Pose
Z44591573 T06
native IFP available
T06
selection_import_t06
0.816 1.000 0.475 native_similarity final_rank_score -16.5317 -0.813918 17 0 Pose
Z44591573 T05
native IFP available
T05
selection_import_t05
0.787 1.000 0.392 native_similarity final_rank_score -25.907 -0.999243 12 5 Pose
Z44591573 T03
native IFP available
T03
selection_import_t03
0.783 1.000 0.380 native_similarity final_rank_score -24.9045 -0.963331 16 3 Pose
Z44591573 T20
native IFP available
T20
selection_import_t20
0.779 1.000 0.369 native_similarity final_rank_score -18.7615 -0.691049 8 6 Pose
Z44591573 T17
native IFP available
T17
selection_import_t17
0.771 1.000 0.345 native_similarity final_rank_score -16.9894 -0.798124 18 3 Pose