FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T15T18
Z30242289
[H]N([H])C(=O)c1ccc(N([H])C(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)cc1
0.918 0.840 3 0.92 0.81 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z30242289
[H]N([H])C(=O)c1ccc(N([H])C(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)cc1
T02
native IFP available
T02
selection_import_t02
0.918 1.000 0.766 native_similarity final_rank_score -25.8019 -0.762875 20 5 Pose
Z30242289
[H]N([H])C(=O)c1ccc(N([H])C(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)cc1
T15
native IFP available
T15
selection_import_t15
0.813 1.000 0.466 native_similarity final_rank_score -23.4114 -0.692566 14 2 Pose
Z30242289
[H]N([H])C(=O)c1ccc(N([H])C(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)cc1
T18
native IFP available
T18
selection_import_t18
0.789 1.000 0.397 native_similarity final_rank_score -17.1876 -0.621096 15 4 Pose