FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T05T06T18
Z29883830 0.859 0.812 4 0.81 0.86 0.80 0.78

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z29883830 T05
native IFP available
T05
selection_import_t05
0.859 1.000 0.599 native_similarity final_rank_score -25.6067 -1.09972 12 6 Pose
Z29883830 T04
native IFP available
T04
selection_import_t04
0.809 1.000 0.454 native_similarity final_rank_score -26.3926 -1.03555 12 2 Pose
Z29883830 T06
native IFP available
T06
selection_import_t06
0.802 1.000 0.433 native_similarity final_rank_score -21.2441 -0.88829 17 0 Pose
Z29883830 T18
native IFP available
T18
selection_import_t18
0.777 1.000 0.362 native_similarity final_rank_score -19.3483 -0.789146 13 5 Pose