FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T05T06T09T13T18
Z223039568 0.838 0.811 5 0.82 0.78 0.83 0.84 0.78

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z223039568 T13
native IFP available
T13
selection_import_t13
0.838 1.000 0.536 native_similarity final_rank_score -27.3958 -1.20644 15 13 Pose
Z223039568 T09
native IFP available
T09
selection_import_t09
0.833 1.000 0.524 native_similarity final_rank_score -22.9764 -1.11872 18 4 Pose
Z223039568 T05
native IFP available
T05
selection_import_t05
0.823 1.000 0.494 native_similarity final_rank_score -27.9441 -1.21466 12 3 Pose
Z223039568 T06
native IFP available
T06
selection_import_t06
0.783 1.000 0.380 native_similarity final_rank_score -23.8 -1.06455 14 1 Pose
Z223039568 T18
native IFP available
T18
selection_import_t18
0.777 1.000 0.362 native_similarity final_rank_score -17.1576 -0.926468 13 4 Pose