FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T09T17
Z20248532 0.848 0.806 3 0.80 0.85 0.77

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z20248532 T09
native IFP available
T09
selection_import_t09
0.848 1.000 0.567 native_similarity final_rank_score -23.9417 -0.787419 14 4 Pose
Z20248532 T03
native IFP available
T03
selection_import_t03
0.799 1.000 0.425 native_similarity final_rank_score -24.8595 -0.834626 13 7 Pose
Z20248532 T17
native IFP available
T17
selection_import_t17
0.771 1.000 0.345 native_similarity final_rank_score -21.2913 -0.724038 18 6 Pose