FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T06T18T20
Z19287096 0.840 0.815 3 0.83 0.77 0.84

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z19287096 T20
native IFP available
T20
selection_import_t20
0.840 1.000 0.542 native_similarity final_rank_score -12.9977 -0.605392 9 5 Pose
Z19287096 T06
native IFP available
T06
selection_import_t06
0.830 1.000 0.515 native_similarity final_rank_score -15.7661 -0.84665 21 1 Pose
Z19287096 T18
native IFP available
T18
selection_import_t18
0.774 1.000 0.353 native_similarity final_rank_score -20.105 -0.62467 14 8 Pose