FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T04T06T09T11T13T17T18T21
Z19160931 0.937 0.866 7 0.81 0.86 0.84 0.81 0.91 0.94 0.90
Z19160931 0.832 0.828 2 0.83 0.82

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z19160931 T17
native IFP available
T17
selection_import_t17
0.937 1.000 0.819 native_similarity final_rank_score -21.5591 -0.9047 17 7 Pose
Z19160931 T13
native IFP available
T13
selection_import_t13
0.906 1.000 0.733 native_similarity final_rank_score -27.5685 -1.02808 17 10 Pose
Z19160931 T21
native IFP available
T21
selection_import_t21
0.897 1.000 0.706 native_similarity final_rank_score -22.9011 -0.897666 17 8 Pose
Z19160931 T04
native IFP available
T04
selection_import_t04
0.860 1.000 0.599 native_similarity final_rank_score -25.2627 -0.978156 13 4 Pose
Z19160931 T06
native IFP available
T06
selection_import_t06
0.839 1.000 0.539 native_similarity final_rank_score -28.033 -1.02513 18 7 Pose
Z19160931 T11
native IFP available
T11
selection_import_t11
0.832 1.000 0.519 native_similarity final_rank_score -24.2779 -0.961841 15 3 Pose
Z19160931 T18
native IFP available
T18
selection_import_t18
0.824 1.000 0.498 native_similarity final_rank_score -25.3195 -0.889785 16 5 Pose
Z19160931 T01
native IFP available
T01
selection_import_t01
0.812 1.000 0.462 native_similarity final_rank_score -23.7513 -0.965287 16 8 Pose
Z19160931 T09
native IFP available
T09
selection_import_t09
0.811 1.000 0.460 native_similarity final_rank_score -22.7928 -0.940194 17 7 Pose