FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 13 best compound-target hits listed 13 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T06T07T08T09T11T12T13T14T17T20
Z18551701 0.900 0.861 4 0.82 0.83 0.90 0.89
Z18551701 0.880 0.844 9 0.86 0.81 0.88 0.82 0.86 0.87 0.85 0.80 0.85

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z18551701 T11
native IFP available
T11
selection_import_t11
0.900 1.000 0.713 native_similarity final_rank_score -21.6251 -0.845392 15 7 Pose
Z18551701 T17
native IFP available
T17
selection_import_t17
0.894 1.000 0.696 native_similarity final_rank_score -17.9154 -0.744151 18 7 Pose
Z18551701 T03
native IFP available
T03
selection_import_t03
0.880 1.000 0.657 native_similarity final_rank_score -27.6652 -0.996473 20 2 Pose
Z18551701 T12
native IFP available
T12
selection_import_t12
0.873 1.000 0.637 native_similarity final_rank_score -24.9893 -0.87636 16 10 Pose
Z18551701 T09
native IFP available
T09
selection_import_t09
0.861 1.000 0.602 native_similarity final_rank_score -25.7656 -0.860182 18 1 Pose
Z18551701 T01
native IFP available
T01
selection_import_t01
0.859 1.000 0.599 native_similarity final_rank_score -27.4139 -0.847561 19 1 Pose
Z18551701 T13
native IFP available
T13
selection_import_t13
0.854 1.000 0.583 native_similarity final_rank_score -24.6186 -0.961077 19 9 Pose
Z18551701 T20
native IFP available
T20
selection_import_t20
0.847 1.000 0.562 native_similarity final_rank_score -16.7251 -0.636352 13 6 Pose
Z18551701 T08
native IFP available
T08
selection_import_t08
0.834 1.000 0.525 native_similarity final_rank_score -23.2357 -1.03109 18 4 Pose
Z18551701 T06
native IFP available
T06
selection_import_t06
0.816 1.000 0.475 native_similarity final_rank_score -22.0344 -0.848526 21 2 Pose
Z18551701 T07
native IFP available
T07
selection_import_t07
0.816 1.000 0.474 native_similarity final_rank_score -23.1066 -0.997941 19 5 Pose
Z18551701 T02
native IFP available
T02
selection_import_t02
0.813 1.000 0.466 native_similarity final_rank_score -22.7668 -0.82458 18 3 Pose
Z18551701 T14
native IFP available
T14
selection_import_t14
0.797 1.000 0.420 native_similarity final_rank_score -19.8725 -0.750771 12 6 Pose