FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T07T10T14
Z18499260 0.938 0.938 1 0.94
Z18499260 0.867 0.824 2 0.87 0.78

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z18499260 T10
native IFP available
T10
selection_import_t10
0.938 1.000 0.823 native_similarity final_rank_score -21.4912 -1.37075 18 12 Pose
Z18499260 T07
native IFP available
T07
selection_import_t07
0.867 1.000 0.619 native_similarity final_rank_score -28.4029 -1.70846 13 9 Pose
Z18499260 T14
native IFP available
T14
selection_import_t14
0.781 1.000 0.373 native_similarity final_rank_score -21.1578 -1.32103 9 10 Pose