FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T09T13T14
Z1541759501 0.865 0.814 3 0.78 0.87 0.80

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z1541759501 T13
native IFP available
T13
selection_import_t13
0.865 1.000 0.616 native_similarity final_rank_score -26.7194 -1.0065 24 4 Pose
Z1541759501 T14
native IFP available
T14
selection_import_t14
0.796 1.000 0.418 native_similarity final_rank_score -18.2508 -0.751552 11 5 Pose
Z1541759501 T09
native IFP available
T09
selection_import_t09
0.782 1.000 0.376 native_similarity final_rank_score -23.9259 -0.840162 16 7 Pose