FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T03T10T11T17T18T19T20T21
Z14345629 0.920 0.828 4 0.80 0.92 0.78 0.81
Z14345629 0.916 0.853 5 0.85 0.87 0.92 0.72 0.92

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z14345629 T10
native IFP available
T10
selection_import_t10
0.920 1.000 0.771 native_similarity final_rank_score -24.8712 -0.829199 16 15 Pose
Z14345629 T17
native IFP available
T17
selection_import_t17
0.916 1.000 0.761 native_similarity final_rank_score -25.494 -0.710741 17 3 Pose
Z14345629 T21
native IFP available
T21
selection_import_t21
0.915 1.000 0.758 native_similarity final_rank_score -27.3115 -0.777835 16 12 Pose
Z14345629 T11
native IFP available
T11
selection_import_t11
0.866 1.000 0.618 native_similarity final_rank_score -25.557 -0.815542 18 3 Pose
Z14345629 T03
native IFP available
T03
selection_import_t03
0.845 1.000 0.558 native_similarity final_rank_score -31.9846 -0.943697 17 4 Pose
Z14345629 T20
native IFP available
T20
selection_import_t20
0.812 1.000 0.463 native_similarity final_rank_score -22.7741 -0.683825 13 4 Pose
Z14345629 T02
native IFP available
T02
selection_import_t02
0.798 1.000 0.424 native_similarity final_rank_score -26.7808 -0.784806 18 1 Pose
Z14345629 T18
native IFP available
T18
selection_import_t18
0.780 1.000 0.373 native_similarity final_rank_score -20.8829 -0.625237 12 5 Pose
Z14345629 T19
native IFP available
T19
selection_import_t19
0.724 1.000 0.213 native_similarity final_rank_score -31.7798 -0.974529 20 9 Pose