FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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3 compounds in matrix 11 best compound-target hits listed 11 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T07T09T11T14T15T17T18T20T22
TC342 0.962 0.873 6 0.81 0.90 0.81 0.90 0.96 0.85
TC342 0.911 0.860 3 0.91 0.84 0.84
TC342 0.847 0.840 2 0.83 0.85

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC342 T20
native IFP available
T20
selection_import_t20
0.962 1.000 0.891 native_similarity final_rank_score -19.2044 -0.575422 11 8 Pose
TC342 T09
native IFP available
T09
selection_import_t09
0.911 1.000 0.745 native_similarity final_rank_score -18.1244 -0.693712 22 9 Pose
TC342 T11
native IFP available
T11
selection_import_t11
0.902 1.000 0.721 native_similarity final_rank_score -16.3266 -0.623182 16 6 Pose
TC342 T17
native IFP available
T17
selection_import_t17
0.901 1.000 0.717 native_similarity final_rank_score -10.5295 -0.663495 22 5 Pose
TC342 T22
native IFP available
T22
selection_import_t22
0.854 1.000 0.584 native_similarity final_rank_score -20.9914 -0.827558 22 7 Pose
TC342 T07
native IFP available
T07
selection_import_t07
0.847 1.000 0.562 native_similarity final_rank_score -21.0594 -0.853891 16 8 Pose
TC342 T15
native IFP available
T15
selection_import_t15
0.835 1.000 0.529 native_similarity final_rank_score -17.0441 -0.628674 14 7 Pose
TC342 T18
native IFP available
T18
selection_import_t18
0.835 1.000 0.529 native_similarity final_rank_score -17.8127 -0.591318 14 6 Pose
TC342 T01
native IFP available
T01
selection_import_t01
0.834 1.000 0.524 native_similarity final_rank_score -15.9309 -0.756631 18 5 Pose
TC342 T14
native IFP available
T14
selection_import_t14
0.812 1.000 0.464 native_similarity final_rank_score -9.73646 -0.614374 16 7 Pose
TC342 T02
native IFP available
T02
selection_import_t02
0.806 1.000 0.446 native_similarity final_rank_score -25.8389 -0.772139 22 10 Pose