FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
Reset
2 compounds in matrix 11 best compound-target hits listed 11 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T04T05T07T09T10T15T17T20T21T22
TC287 0.960 0.895 3 0.78 0.96 0.94
TC287 0.859 0.787 8 0.76 0.82 0.86 0.84 0.74 0.71 0.81 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC287 T10
native IFP available
T10
selection_import_t10
0.960 1.000 0.887 native_similarity final_rank_score -25.7697 -1.8538 18 14 Pose
TC287 T21
native IFP available
T21
selection_import_t21
0.942 1.000 0.834 native_similarity final_rank_score -24.4385 -1.69567 14 11 Pose
TC287 T07
native IFP available
T07
selection_import_t07
0.859 1.000 0.598 native_similarity final_rank_score -28.0856 -1.90731 14 6 Pose
TC287 T09
native IFP available
T09
selection_import_t09
0.837 1.000 0.533 native_similarity final_rank_score -23.9391 -1.65348 15 9 Pose
TC287 T04
native IFP available
T04
selection_import_t04
0.821 1.000 0.488 native_similarity final_rank_score -27.0217 -1.85909 10 5 Pose
TC287 T20
native IFP available
T20
selection_import_t20
0.805 1.000 0.443 native_similarity final_rank_score -17.6237 -1.12148 9 6 Pose
TC287 T05
native IFP available
T05
selection_import_t05
0.784 1.000 0.384 native_similarity final_rank_score -32.3055 -2.05461 11 10 Pose
TC287 T03
native IFP available
T03
selection_import_t03
0.762 1.000 0.319 native_similarity final_rank_score -26.7391 -1.715 11 9 Pose
TC287 T22
native IFP available
T22
selection_import_t22
0.759 1.000 0.312 native_similarity final_rank_score -29.6982 -1.85546 17 13 Pose
TC287 T15
native IFP available
T15
selection_import_t15
0.743 1.000 0.265 native_similarity final_rank_score -23.0442 -1.49117 12 7 Pose
TC287 T17
native IFP available
T17
selection_import_t17
0.709 1.000 0.170 native_similarity final_rank_score -24.4615 -1.32219 15 9 Pose