FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T15T20
ulfkktlib_690 0.922 0.831 4 0.80 0.82 0.79 0.92

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
ulfkktlib_690 T20
native IFP available
T20
selection_import_t20
0.922 1.000 0.778 native_similarity final_rank_score -18.014 -0.622397 12 4 Pose
ulfkktlib_690 T02
native IFP available
T02
selection_import_t02
0.819 1.000 0.484 native_similarity final_rank_score -24.8366 -0.8645 18 2 Pose
ulfkktlib_690 T01
native IFP available
T01
selection_import_t01
0.798 1.000 0.423 native_similarity final_rank_score -24.9787 -0.86574 16 2 Pose
ulfkktlib_690 T15
native IFP available
T15
selection_import_t15
0.786 1.000 0.388 native_similarity final_rank_score -25.0861 -0.877591 16 1 Pose