FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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3 compounds in matrix 4 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T07T19
ulfkktlib_3079 0.855 0.846 2 0.85 0.84
ulfkktlib_3075 0.847 0.847 1 0.85
ulfkktlib_307 0.727 0.727 1 0.73

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
ulfkktlib_3079 T04
native IFP available
T04
selection_import_t04
0.855 1.000 0.585 native_similarity final_rank_score -18.6936 -1.25455 11 10 Pose
ulfkktlib_3075 T07
native IFP available
T07
selection_import_t07
0.847 1.000 0.562 native_similarity final_rank_score -26.4059 -1.76831 10 7 Pose
ulfkktlib_3079 T07
native IFP available
T07
selection_import_t07
0.837 1.000 0.534 native_similarity final_rank_score -29.5327 -1.65418 12 8 Pose
ulfkktlib_307 T19
native IFP available
T19
selection_import_t19
0.727 1.000 0.221 native_similarity final_rank_score -31.7398 -1.34898 16 5 Pose