FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T05T19T22
ulfkktlib_2489 0.841 0.801 4 0.81 0.84 0.74 0.82

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
ulfkktlib_2489 T05
native IFP available
T05
selection_import_t05
0.841 1.000 0.545 native_similarity final_rank_score -30.5603 -0.879151 12 7 Pose
ulfkktlib_2489 T22
native IFP available
T22
selection_import_t22
0.820 1.000 0.486 native_similarity final_rank_score -29.1007 -0.878582 18 12 Pose
ulfkktlib_2489 T03
native IFP available
T03
selection_import_t03
0.805 1.000 0.443 native_similarity final_rank_score -29.2528 -0.823205 18 1 Pose
ulfkktlib_2489 T19
native IFP available
T19
selection_import_t19
0.738 1.000 0.251 native_similarity final_rank_score -35.308 -1.0007 24 7 Pose