FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T10T21
ulfkktlib_169 0.935 0.934 2 0.93 0.93
ulfkktlib_1694 0.790 0.790 1 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
ulfkktlib_169 T10
native IFP available
T10
selection_import_t10
0.935 1.000 0.814 native_similarity final_rank_score -22.7912 -0.845324 18 11 Pose
ulfkktlib_169 T21
native IFP available
T21
selection_import_t21
0.934 1.000 0.811 native_similarity final_rank_score -20.2477 -0.864012 14 8 Pose
ulfkktlib_1694 T04
native IFP available
T04
selection_import_t04
0.790 1.000 0.401 native_similarity final_rank_score -27.3426 -3.4304 6 10 Pose