FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
Reset
1 compounds in matrix 1 best compound-target hits listed 1 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04
ulfkktlib_1677
[H]N(CCc1c(C(=O)N([H])CCCN2CCCC2=O)cnn1-c1ccccc1)C(=O)OC(C)(C)C
0.835 0.835 1 0.84

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
ulfkktlib_1677
[H]N(CCc1c(C(=O)N([H])CCCN2CCCC2=O)cnn1-c1ccccc1)C(=O)OC(C)(C)C
T04
native IFP available
T04
selection_import_t04
0.835 1.000 0.529 native_similarity final_rank_score -21.6511 -0.746107 13 4 Pose