FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T09T11T12T16T22
Z87656593 0.919 0.912 2 0.90 0.92
Z87656593 0.875 0.813 3 0.88 0.84 0.73

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z87656593 T22
native IFP available
T22
selection_import_t22
0.919 1.000 0.770 native_similarity final_rank_score -34.6245 -1.30783 22 10 Pose
Z87656593 T12
native IFP available
T12
selection_import_t12
0.904 1.000 0.727 native_similarity final_rank_score -27.4884 -0.963748 18 13 Pose
Z87656593 T09
native IFP available
T09
selection_import_t09
0.875 1.000 0.643 native_similarity final_rank_score -23.2748 -0.926792 16 7 Pose
Z87656593 T11
native IFP available
T11
selection_import_t11
0.836 1.000 0.530 native_similarity final_rank_score -21.9787 -0.879661 18 6 Pose
Z87656593 T16
native IFP available
T16
selection_import_t16
0.729 1.000 0.225 native_similarity final_rank_score -24.5022 -0.934815 13 5 Pose