FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T11T19
Z57728363
[H]OCc1cc(=O)c(O[H])c([C@@H](c2cccc(OC)c2)N([H])c2cccc[n+]2[H])o1
0.896 0.896 1 0.90
Z57728363
[H]OCc1cc(=O)c(O[H])c([C@H](c2cccc(OC)c2)N([H])c2cccc[n+]2[H])o1
0.724 0.724 1 0.72

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57728363
[H]OCc1cc(=O)c(O[H])c([C@@H](c2cccc(OC)c2)N([H])c2cccc[n+]2[H])o1
T11
native IFP available
T11
selection_import_t11
0.896 1.000 0.702 native_similarity final_rank_score -21.4192 -0.947248 12 7 Pose
Z57728363
[H]OCc1cc(=O)c(O[H])c([C@H](c2cccc(OC)c2)N([H])c2cccc[n+]2[H])o1
T19
native IFP available
T19
selection_import_t19
0.724 1.000 0.211 native_similarity final_rank_score -32.721 -1.36498 21 7 Pose