FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 14 best compound-target hits listed 14 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T06T07T08T09T11T14T15T16T17T18T19T20T22
Z57457889 0.923 0.821 9 0.78 0.80 0.84 0.83 0.79 0.92 0.78 0.80 0.84
Z57457889 0.784 0.751 5 0.78 0.74 0.74 0.71 0.78

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57457889 T11
native IFP available
T11
selection_import_t11
0.923 1.000 0.779 native_similarity final_rank_score -20.21 -0.907256 14 8 Pose
Z57457889 T07
native IFP available
T07
selection_import_t07
0.842 1.000 0.549 native_similarity final_rank_score -30.2356 -1.11733 13 4 Pose
Z57457889 T22
native IFP available
T22
selection_import_t22
0.838 1.000 0.538 native_similarity final_rank_score -29.1943 -1.02476 22 16 Pose
Z57457889 T08
native IFP available
T08
selection_import_t08
0.835 1.000 0.528 native_similarity final_rank_score -36.6273 -1.13404 15 9 Pose
Z57457889 T18
native IFP available
T18
selection_import_t18
0.804 1.000 0.441 native_similarity final_rank_score -23.9664 -0.848983 16 4 Pose
Z57457889 T06
native IFP available
T06
selection_import_t06
0.798 1.000 0.424 native_similarity final_rank_score -16.0129 -0.797896 18 3 Pose
Z57457889 T09
native IFP available
T09
selection_import_t09
0.785 1.000 0.386 native_similarity final_rank_score -28.1676 -0.936064 18 4 Pose
Z57457889 T14
native IFP available
T14
selection_import_t14
0.784 1.000 0.384 native_similarity final_rank_score -20.7486 -0.796377 19 3 Pose
Z57457889 T03
native IFP available
T03
selection_import_t03
0.782 1.000 0.377 native_similarity final_rank_score -31.8463 -1.07372 14 6 Pose
Z57457889 T20
native IFP available
T20
selection_import_t20
0.779 1.000 0.369 native_similarity final_rank_score -20.6493 -0.670596 8 8 Pose
Z57457889 T15
native IFP available
T15
selection_import_t15
0.777 1.000 0.362 native_similarity final_rank_score -20.0016 -0.774253 13 6 Pose
Z57457889 T16
native IFP available
T16
selection_import_t16
0.745 1.000 0.270 native_similarity final_rank_score -23.1476 -0.765173 14 4 Pose
Z57457889 T17
native IFP available
T17
selection_import_t17
0.739 1.000 0.254 native_similarity final_rank_score -23.4879 -0.777505 17 5 Pose
Z57457889 T19
native IFP available
T19
selection_import_t19
0.709 1.000 0.169 native_similarity final_rank_score -30.6961 -1.05411 21 4 Pose