FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T10
Z57201291
[H]OC[C@H](O)[C@@H]1OC(=O)C(O)=C1O[H]
0.944 0.944 1 0.94
Z57201291
[H]OC[C@@H](O[H])[C@@H]1OC(=O)C(O[H])=C1O
0.787 0.787 1 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57201291
[H]OC[C@H](O)[C@@H]1OC(=O)C(O)=C1O[H]
T10
native IFP available
T10
selection_import_t10
0.944 1.000 0.841 native_similarity final_rank_score -23.395 -2.10985 16 13 Pose
Z57201291
[H]OC[C@@H](O[H])[C@@H]1OC(=O)C(O[H])=C1O
T04
native IFP available
T04
selection_import_t04
0.787 1.000 0.391 native_similarity final_rank_score -26.1604 -2.29011 8 8 Pose