FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
Reset
2 compounds in matrix 10 best compound-target hits listed 10 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T05T07T09T11T13T14T15T20T21
Z57183373 0.910 0.858 8 0.87 0.83 0.90 0.80 0.89 0.85 0.80 0.91
Z57183373 0.904 0.836 2 0.77 0.90

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57183373 T21
native IFP available
T21
selection_import_t21
0.910 1.000 0.743 native_similarity final_rank_score -28.5222 -1.35257 14 12 Pose
Z57183373 T20
native IFP available
T20
selection_import_t20
0.904 1.000 0.725 native_similarity final_rank_score -17.0893 -0.896774 10 6 Pose
Z57183373 T07
native IFP available
T07
selection_import_t07
0.900 1.000 0.716 native_similarity final_rank_score -29.3424 -1.53558 17 10 Pose
Z57183373 T11
native IFP available
T11
selection_import_t11
0.891 1.000 0.688 native_similarity final_rank_score -23.9773 -1.15154 11 9 Pose
Z57183373 T01
native IFP available
T01
selection_import_t01
0.874 1.000 0.639 native_similarity final_rank_score -24.8475 -1.3035 17 6 Pose
Z57183373 T13
native IFP available
T13
selection_import_t13
0.855 1.000 0.584 native_similarity final_rank_score -28.2583 -1.35351 16 6 Pose
Z57183373 T05
native IFP available
T05
selection_import_t05
0.830 1.000 0.514 native_similarity final_rank_score -34.097 -1.61054 12 11 Pose
Z57183373 T09
native IFP available
T09
selection_import_t09
0.804 1.000 0.440 native_similarity final_rank_score -24.2204 -1.21353 14 8 Pose
Z57183373 T15
native IFP available
T15
selection_import_t15
0.801 1.000 0.433 native_similarity final_rank_score -23.4955 -1.13114 12 8 Pose
Z57183373 T14
native IFP available
T14
selection_import_t14
0.769 1.000 0.340 native_similarity final_rank_score -22.935 -1.20529 12 7 Pose