FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 7 best compound-target hits listed 7 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T05T06T07T08T10T22
Z57100312 0.879 0.871 3 0.87 0.88 0.86
Z57100312 0.860 0.816 4 0.76 0.85 0.80 0.86

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57100312 T10
native IFP available
T10
selection_import_t10
0.879 1.000 0.655 native_similarity final_rank_score -26.4883 -1.10054 14 12 Pose
Z57100312 T08
native IFP available
T08
selection_import_t08
0.873 1.000 0.638 native_similarity final_rank_score -31.4693 -1.43345 16 8 Pose
Z57100312 T22
native IFP available
T22
selection_import_t22
0.860 1.000 0.601 native_similarity final_rank_score -29.1891 -1.34006 18 8 Pose
Z57100312 T07
native IFP available
T07
selection_import_t07
0.860 1.000 0.599 native_similarity final_rank_score -31.6503 -1.41746 13 9 Pose
Z57100312 T05
native IFP available
T05
selection_import_t05
0.846 1.000 0.559 native_similarity final_rank_score -33.9025 -1.21755 11 8 Pose
Z57100312 T06
native IFP available
T06
selection_import_t06
0.798 1.000 0.424 native_similarity final_rank_score -23.8769 -0.956222 18 3 Pose
Z57100312 T03
native IFP available
T03
selection_import_t03
0.760 1.000 0.313 native_similarity final_rank_score -27.9383 -1.11361 12 5 Pose