FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T06
Z56893343 0.827 0.812 3 0.81 0.80 0.83

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56893343 T06
native IFP available
T06
selection_import_t06
0.827 1.000 0.507 native_similarity final_rank_score -17.0472 -0.781117 18 2 Pose
Z56893343 T01
native IFP available
T01
selection_import_t01
0.809 1.000 0.454 native_similarity final_rank_score -21.0567 -0.783787 19 2 Pose
Z56893343 T02
native IFP available
T02
selection_import_t02
0.798 1.000 0.424 native_similarity final_rank_score -20.2938 -0.769292 18 2 Pose