FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T05T19
Z56842351
[H]N(c1cccc(C(F)(F)F)c1)[C@@H](c1ccncc1)c1ccc2cccnc2c1O
0.831 0.831 1 0.83
Z56842351
[H]Oc1c([C@@H](c2ccncc2)N([H])c2cccc(C(F)(F)F)c2)ccc2cccnc12
0.726 0.726 1 0.73

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56842351
[H]N(c1cccc(C(F)(F)F)c1)[C@@H](c1ccncc1)c1ccc2cccnc2c1O
T05
native IFP available
T05
selection_import_t05
0.831 1.000 0.518 native_similarity final_rank_score -30.0851 -1.02009 14 4 Pose
Z56842351
[H]Oc1c([C@@H](c2ccncc2)N([H])c2cccc(C(F)(F)F)c2)ccc2cccnc12
T19
native IFP available
T19
selection_import_t19
0.726 1.000 0.216 native_similarity final_rank_score -29.3955 -1.07308 18 4 Pose