FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 21 best compound-target hits listed 21 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T04T05T06T07T08T09T10T11T12T13T14T15T16T17T18T20T21T22
Z56833421 0.941 0.845 12 0.81 0.81 0.83 0.94 0.82 0.93 0.83 0.74 0.88 0.77 0.89 0.89
Z56833421 0.914 0.830 9 0.77 0.81 0.85 0.90 0.91 0.76 0.84 0.71 0.91

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56833421 T10
native IFP available
T10
selection_import_t10
0.941 1.000 0.832 native_similarity final_rank_score -27.9889 -1.11454 18 13 Pose
Z56833421 T12
native IFP available
T12
selection_import_t12
0.927 1.000 0.792 native_similarity final_rank_score -29.589 -1.14702 14 14 Pose
Z56833421 T22
native IFP available
T22
selection_import_t22
0.914 1.000 0.754 native_similarity final_rank_score -27.5218 -1.24435 25 13 Pose
Z56833421 T08
native IFP available
T08
selection_import_t08
0.906 1.000 0.733 native_similarity final_rank_score -38.8504 -1.47787 15 14 Pose
Z56833421 T07
native IFP available
T07
selection_import_t07
0.901 1.000 0.717 native_similarity final_rank_score -41.9215 -1.64167 16 15 Pose
Z56833421 T20
native IFP available
T20
selection_import_t20
0.890 1.000 0.685 native_similarity final_rank_score -19.9768 -0.991863 13 10 Pose
Z56833421 T21
native IFP available
T21
selection_import_t21
0.887 1.000 0.678 native_similarity final_rank_score -24.8429 -1.07884 15 11 Pose
Z56833421 T17
native IFP available
T17
selection_import_t17
0.878 1.000 0.652 native_similarity final_rank_score -20.868 -0.869936 17 10 Pose
Z56833421 T05
native IFP available
T05
selection_import_t05
0.851 1.000 0.574 native_similarity final_rank_score -29.071 -1.25865 14 12 Pose
Z56833421 T13
native IFP available
T13
selection_import_t13
0.842 1.000 0.548 native_similarity final_rank_score -31.2421 -1.24622 20 10 Pose
Z56833421 T14
native IFP available
T14
selection_import_t14
0.833 1.000 0.524 native_similarity final_rank_score -28.813 -1.08851 16 14 Pose
Z56833421 T06
native IFP available
T06
selection_import_t06
0.828 1.000 0.508 native_similarity final_rank_score -18.5492 -0.876062 17 5 Pose
Z56833421 T11
native IFP available
T11
selection_import_t11
0.819 1.000 0.483 native_similarity final_rank_score -24.7592 -1.0041 16 6 Pose
Z56833421 T01
native IFP available
T01
selection_import_t01
0.811 1.000 0.460 native_similarity final_rank_score -22.1499 -1.04513 14 6 Pose
Z56833421 T02
native IFP available
T02
selection_import_t02
0.811 1.000 0.460 native_similarity final_rank_score -23.1894 -1.01549 14 6 Pose
Z56833421 T04
native IFP available
T04
selection_import_t04
0.809 1.000 0.454 native_similarity final_rank_score -25.5318 -0.968374 12 2 Pose
Z56833421 T03
native IFP available
T03
selection_import_t03
0.771 1.000 0.345 native_similarity final_rank_score -25.1652 -1.16799 13 9 Pose
Z56833421 T18
native IFP available
T18
selection_import_t18
0.771 1.000 0.345 native_similarity final_rank_score -19.4559 -0.939152 15 10 Pose
Z56833421 T09
native IFP available
T09
selection_import_t09
0.764 1.000 0.326 native_similarity final_rank_score -27.514 -1.06544 16 7 Pose
Z56833421 T15
native IFP available
T15
selection_import_t15
0.738 1.000 0.253 native_similarity final_rank_score -20.6734 -0.904088 14 8 Pose
Z56833421 T16
native IFP available
T16
selection_import_t16
0.713 1.000 0.180 native_similarity final_rank_score -20.5964 -1.02633 12 11 Pose