FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 18 best compound-target hits listed 18 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T04T05T06T07T08T09T11T12T14T15T17T18T20T21T22
Z56821211 0.940 0.841 7 0.78 0.87 0.85 0.86 0.79 0.79 0.94
Z56821211 0.922 0.834 11 0.82 0.81 0.80 0.81 0.87 0.90 0.81 0.79 0.76 0.89 0.92

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56821211 T22
native IFP available
T22
selection_import_t22
0.940 1.000 0.829 native_similarity final_rank_score -29.8721 -1.33508 23 12 Pose
Z56821211 T21
native IFP available
T21
selection_import_t21
0.922 1.000 0.776 native_similarity final_rank_score -24.739 -1.08342 17 13 Pose
Z56821211 T12
native IFP available
T12
selection_import_t12
0.902 1.000 0.719 native_similarity final_rank_score -26.3483 -1.0718 13 8 Pose
Z56821211 T20
native IFP available
T20
selection_import_t20
0.890 1.000 0.685 native_similarity final_rank_score -23.3189 -0.959593 13 11 Pose
Z56821211 T05
native IFP available
T05
selection_import_t05
0.870 1.000 0.627 native_similarity final_rank_score -27.5859 -1.2484 14 9 Pose
Z56821211 T11
native IFP available
T11
selection_import_t11
0.867 1.000 0.620 native_similarity final_rank_score -24.3015 -1.1021 20 6 Pose
Z56821211 T08
native IFP available
T08
selection_import_t08
0.862 1.000 0.607 native_similarity final_rank_score -34.5795 -1.35261 20 9 Pose
Z56821211 T07
native IFP available
T07
selection_import_t07
0.855 1.000 0.585 native_similarity final_rank_score -32.2148 -1.32744 18 8 Pose
Z56821211 T02
native IFP available
T02
selection_import_t02
0.825 1.000 0.500 native_similarity final_rank_score -24.9584 -1.02364 15 5 Pose
Z56821211 T03
native IFP available
T03
selection_import_t03
0.813 1.000 0.465 native_similarity final_rank_score -26.4832 -1.08162 16 3 Pose
Z56821211 T14
native IFP available
T14
selection_import_t14
0.807 1.000 0.448 native_similarity final_rank_score -27.725 -1.1213 12 10 Pose
Z56821211 T06
native IFP available
T06
selection_import_t06
0.805 1.000 0.443 native_similarity final_rank_score -24.115 -0.923569 16 1 Pose
Z56821211 T04
native IFP available
T04
selection_import_t04
0.800 1.000 0.428 native_similarity final_rank_score -20.7811 -1.02585 12 11 Pose
Z56821211 T18
native IFP available
T18
selection_import_t18
0.793 1.000 0.408 native_similarity final_rank_score -13.9538 -0.833997 14 3 Pose
Z56821211 T09
native IFP available
T09
selection_import_t09
0.791 1.000 0.403 native_similarity final_rank_score -25.6511 -1.11196 14 5 Pose
Z56821211 T15
native IFP available
T15
selection_import_t15
0.786 1.000 0.388 native_similarity final_rank_score -20.509 -1.0052 16 6 Pose
Z56821211 T01
native IFP available
T01
selection_import_t01
0.780 1.000 0.371 native_similarity final_rank_score -22.6416 -1.05323 15 5 Pose
Z56821211 T17
native IFP available
T17
selection_import_t17
0.756 1.000 0.302 native_similarity final_rank_score -17.5343 -0.922081 17 5 Pose