FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T05T07T12T14T17T19T21T22
Z56765335 0.935 0.835 3 0.81 0.93 0.76
Z56765335 0.902 0.817 6 0.85 0.84 0.77 0.75 0.90 0.80

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56765335 T12
native IFP available
T12
selection_import_t12
0.935 1.000 0.814 native_similarity final_rank_score -30.328 -1.11523 16 14 Pose
Z56765335 T21
native IFP available
T21
selection_import_t21
0.902 1.000 0.720 native_similarity final_rank_score -22.4375 -0.914601 15 9 Pose
Z56765335 T05
native IFP available
T05
selection_import_t05
0.847 1.000 0.564 native_similarity final_rank_score -25.0914 -1.05774 15 8 Pose
Z56765335 T07
native IFP available
T07
selection_import_t07
0.840 1.000 0.542 native_similarity final_rank_score -25.8264 -1.13873 18 7 Pose
Z56765335 T03
native IFP available
T03
selection_import_t03
0.811 1.000 0.461 native_similarity final_rank_score -25.6366 -0.954005 16 5 Pose
Z56765335 T22
native IFP available
T22
selection_import_t22
0.798 1.000 0.423 native_similarity final_rank_score -27.8624 -1.11435 18 7 Pose
Z56765335 T14
native IFP available
T14
selection_import_t14
0.767 1.000 0.333 native_similarity final_rank_score -21.8999 -0.813135 13 4 Pose
Z56765335 T17
native IFP available
T17
selection_import_t17
0.758 1.000 0.308 native_similarity final_rank_score -23.2531 -0.815998 16 3 Pose
Z56765335 T19
native IFP available
T19
selection_import_t19
0.747 1.000 0.276 native_similarity final_rank_score -26.424 -1.20032 20 8 Pose