FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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4 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T07T11T13T14T15T16T19T20T21
Z56174642 0.896 0.833 3 0.83 0.77 0.90
Z56174642 0.810 0.810 1 0.81
Z56174642 0.803 0.759 4 0.74 0.77 0.73 0.80
Z56174642 0.769 0.769 1 0.77

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56174642 T21
native IFP available
T21
selection_import_t21
0.896 1.000 0.704 native_similarity final_rank_score -24.2954 -0.968206 12 8 Pose
Z56174642 T13
native IFP available
T13
selection_import_t13
0.828 1.000 0.508 native_similarity final_rank_score -28.0995 -1.10448 15 9 Pose
Z56174642 T07
native IFP available
T07
selection_import_t07
0.810 1.000 0.458 native_similarity final_rank_score -28.7598 -1.23843 16 2 Pose
Z56174642 T20
native IFP available
T20
selection_import_t20
0.803 1.000 0.438 native_similarity final_rank_score -18.1945 -0.857541 5 8 Pose
Z56174642 T15
native IFP available
T15
selection_import_t15
0.774 1.000 0.353 native_similarity final_rank_score -24.1229 -1.0217 14 6 Pose
Z56174642 T14
native IFP available
T14
selection_import_t14
0.772 1.000 0.347 native_similarity final_rank_score -21.8179 -0.924102 11 5 Pose
Z56174642 T16
native IFP available
T16
selection_import_t16
0.769 1.000 0.340 native_similarity final_rank_score -20.4477 -0.961151 12 4 Pose
Z56174642 T11
native IFP available
T11
selection_import_t11
0.738 1.000 0.252 native_similarity final_rank_score -23.6767 -1.01467 17 4 Pose
Z56174642 T19
native IFP available
T19
selection_import_t19
0.725 1.000 0.215 native_similarity final_rank_score -32.8697 -1.40043 19 7 Pose