FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T11T14T16T20
Z54322503 0.872 0.818 3 0.87 0.77 0.81
Z54322503 0.841 0.783 2 0.84 0.73

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z54322503 T11
native IFP available
T11
selection_import_t11
0.872 1.000 0.636 native_similarity final_rank_score -17.6049 -0.682717 13 5 Pose
Z54322503 T03
native IFP available
T03
selection_import_t03
0.841 1.000 0.546 native_similarity final_rank_score -27.4335 -0.761962 18 4 Pose
Z54322503 T20
native IFP available
T20
selection_import_t20
0.812 1.000 0.463 native_similarity final_rank_score -21.4545 -0.585945 13 5 Pose
Z54322503 T14
native IFP available
T14
selection_import_t14
0.768 1.000 0.339 native_similarity final_rank_score -19.4069 -0.656142 20 3 Pose
Z54322503 T16
native IFP available
T16
selection_import_t16
0.726 1.000 0.216 native_similarity final_rank_score -25.3968 -0.662262 15 6 Pose