FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 11 best compound-target hits listed 11 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T05T07T09T10T13T14T18T19
Z49890540 0.868 0.823 4 0.85 0.87 0.87 0.71
Z49890540 0.858 0.790 7 0.85 0.86 0.74 0.85 0.71 0.75 0.78

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49890540 T10
native IFP available
T10
selection_import_t10
0.868 1.000 0.624 native_similarity final_rank_score -18.9968 -1.0344 16 6 Pose
Z49890540 T13
native IFP available
T13
selection_import_t13
0.868 1.000 0.622 native_similarity final_rank_score -34.9829 -1.19183 15 10 Pose
Z49890540 T02
native IFP available
T02
selection_import_t02
0.858 1.000 0.593 native_similarity final_rank_score -25.5113 -1.02909 16 4 Pose
Z49890540 T07
native IFP available
T07
selection_import_t07
0.847 1.000 0.562 native_similarity final_rank_score -29.7382 -1.27135 12 5 Pose
Z49890540 T01
native IFP available
T01
selection_import_t01
0.846 1.000 0.560 native_similarity final_rank_score -28.2176 -1.13378 15 3 Pose
Z49890540 T05
native IFP available
T05
selection_import_t05
0.846 1.000 0.559 native_similarity final_rank_score -30.5873 -1.20291 11 7 Pose
Z49890540 T18
native IFP available
T18
selection_import_t18
0.777 1.000 0.362 native_similarity final_rank_score -18.6899 -0.830152 13 4 Pose
Z49890540 T14
native IFP available
T14
selection_import_t14
0.751 1.000 0.289 native_similarity final_rank_score -22.4323 -0.887757 13 8 Pose
Z49890540 T03
native IFP available
T03
selection_import_t03
0.739 1.000 0.254 native_similarity final_rank_score -27.4314 -1.13978 9 7 Pose
Z49890540 T09
native IFP available
T09
selection_import_t09
0.712 1.000 0.178 native_similarity final_rank_score -24.4722 -1.05666 11 5 Pose
Z49890540 T19
native IFP available
T19
selection_import_t19
0.712 1.000 0.178 native_similarity final_rank_score -33.0521 -1.25853 17 6 Pose