FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 11 best compound-target hits listed 11 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T04T07T09T10T11T12T13T16T17T22
Z49597823 0.921 0.859 6 0.84 0.92 0.87 0.89 0.78 0.86
Z49597823 0.852 0.809 5 0.80 0.83 0.79 0.85 0.78

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49597823 T10
native IFP available
T10
selection_import_t10
0.921 1.000 0.774 native_similarity final_rank_score -20.1581 -0.634517 18 11 Pose
Z49597823 T13
native IFP available
T13
selection_import_t13
0.888 1.000 0.680 native_similarity final_rank_score -22.3926 -0.711207 22 8 Pose
Z49597823 T11
native IFP available
T11
selection_import_t11
0.868 1.000 0.624 native_similarity final_rank_score -26.5323 -0.682535 15 7 Pose
Z49597823 T22
native IFP available
T22
selection_import_t22
0.860 1.000 0.601 native_similarity final_rank_score -34.339 -0.82917 18 10 Pose
Z49597823 T12
native IFP available
T12
selection_import_t12
0.852 1.000 0.577 native_similarity final_rank_score -22.0084 -0.691741 16 7 Pose
Z49597823 T04
native IFP available
T04
selection_import_t04
0.839 1.000 0.539 native_similarity final_rank_score -25.0747 -0.617165 13 3 Pose
Z49597823 T07
native IFP available
T07
selection_import_t07
0.831 1.000 0.518 native_similarity final_rank_score -34.6794 -0.836047 19 4 Pose
Z49597823 T02
native IFP available
T02
selection_import_t02
0.798 1.000 0.424 native_similarity final_rank_score -19.891 -0.695886 18 3 Pose
Z49597823 T09
native IFP available
T09
selection_import_t09
0.785 1.000 0.386 native_similarity final_rank_score -29.0018 -0.733243 18 4 Pose
Z49597823 T16
native IFP available
T16
selection_import_t16
0.779 1.000 0.368 native_similarity final_rank_score -14.1151 -0.58979 15 3 Pose
Z49597823 T17
native IFP available
T17
selection_import_t17
0.777 1.000 0.363 native_similarity final_rank_score -28.2621 -0.709367 23 7 Pose