FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 13 best compound-target hits listed 13 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T03T04T07T08T10T11T13T14T15T17T18T21
Z49549408 0.872 0.821 8 0.74 0.85 0.87 0.85 0.86 0.78 0.76 0.86
Z49549408 0.858 0.799 5 0.86 0.83 0.84 0.71 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49549408 T10
native IFP available
T10
selection_import_t10
0.872 1.000 0.633 native_similarity final_rank_score -25.5076 -1.45975 13 10 Pose
Z49549408 T13
native IFP available
T13
selection_import_t13
0.863 1.000 0.607 native_similarity final_rank_score -27.2831 -1.69221 18 9 Pose
Z49549408 T01
native IFP available
T01
selection_import_t01
0.858 1.000 0.593 native_similarity final_rank_score -20.6775 -1.36652 16 7 Pose
Z49549408 T21
native IFP available
T21
selection_import_t21
0.856 1.000 0.588 native_similarity final_rank_score -23.0255 -1.28583 14 8 Pose
Z49549408 T04
native IFP available
T04
selection_import_t04
0.854 1.000 0.582 native_similarity final_rank_score -22.3757 -1.31937 12 8 Pose
Z49549408 T11
native IFP available
T11
selection_import_t11
0.845 1.000 0.558 native_similarity final_rank_score -21.824 -1.25917 11 6 Pose
Z49549408 T08
native IFP available
T08
selection_import_t08
0.841 1.000 0.546 native_similarity final_rank_score -28.8386 -1.79613 12 13 Pose
Z49549408 T07
native IFP available
T07
selection_import_t07
0.829 1.000 0.512 native_similarity final_rank_score -32.786 -2.09147 11 13 Pose
Z49549408 T14
native IFP available
T14
selection_import_t14
0.783 1.000 0.380 native_similarity final_rank_score -21.767 -1.38191 13 5 Pose
Z49549408 T18
native IFP available
T18
selection_import_t18
0.758 1.000 0.309 native_similarity final_rank_score -14.7248 -1.11219 13 10 Pose
Z49549408 T15
native IFP available
T15
selection_import_t15
0.756 1.000 0.302 native_similarity final_rank_score -21.0928 -1.23753 14 5 Pose
Z49549408 T03
native IFP available
T03
selection_import_t03
0.738 1.000 0.250 native_similarity final_rank_score -21.6428 -1.46812 10 9 Pose
Z49549408 T17
native IFP available
T17
selection_import_t17
0.710 1.000 0.173 native_similarity final_rank_score -10.6357 -1.20883 14 9 Pose