FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 8 best compound-target hits listed 8 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T04T07T09T11T12T15T21
Z46589685 0.896 0.839 5 0.75 0.86 0.81 0.90 0.89
Z46589685 0.870 0.831 3 0.83 0.87 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z46589685 T12
native IFP available
T12
selection_import_t12
0.896 1.000 0.702 native_similarity final_rank_score -23.9442 -0.999965 18 9 Pose
Z46589685 T21
native IFP available
T21
selection_import_t21
0.885 1.000 0.672 native_similarity final_rank_score -19.8413 -0.918609 17 8 Pose
Z46589685 T11
native IFP available
T11
selection_import_t11
0.870 1.000 0.628 native_similarity final_rank_score -21.1826 -0.84409 19 4 Pose
Z46589685 T07
native IFP available
T07
selection_import_t07
0.863 1.000 0.608 native_similarity final_rank_score -31.4622 -1.24423 16 7 Pose
Z46589685 T04
native IFP available
T04
selection_import_t04
0.830 1.000 0.514 native_similarity final_rank_score -19.6588 -0.850383 12 5 Pose
Z46589685 T09
native IFP available
T09
selection_import_t09
0.806 1.000 0.445 native_similarity final_rank_score -24.5137 -0.96178 20 5 Pose
Z46589685 T15
native IFP available
T15
selection_import_t15
0.793 1.000 0.408 native_similarity final_rank_score -17.6095 -0.83616 14 8 Pose
Z46589685 T01
native IFP available
T01
selection_import_t01
0.748 1.000 0.279 native_similarity final_rank_score -23.9647 -0.961388 12 5 Pose