FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
Reset
2 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T06T11T13T14T16T18T20
Z46080221 0.892 0.866 2 0.89 0.84
Z46080221 0.864 0.814 7 0.83 0.86 0.81 0.86 0.80 0.78 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z46080221 T13
native IFP available
T13
selection_import_t13
0.892 1.000 0.691 native_similarity final_rank_score -18.5175 -1.00638 21 7 Pose
Z46080221 T02
native IFP available
T02
selection_import_t02
0.864 1.000 0.612 native_similarity final_rank_score -26.8305 -0.927177 18 2 Pose
Z46080221 T11
native IFP available
T11
selection_import_t11
0.863 1.000 0.609 native_similarity final_rank_score -25.123 -0.820596 14 2 Pose
Z46080221 T20
native IFP available
T20
selection_import_t20
0.841 1.000 0.546 native_similarity final_rank_score -19.4563 -0.656543 13 4 Pose
Z46080221 T01
native IFP available
T01
selection_import_t01
0.826 1.000 0.503 native_similarity final_rank_score -24.6779 -0.882085 16 2 Pose
Z46080221 T06
native IFP available
T06
selection_import_t06
0.805 1.000 0.443 native_similarity final_rank_score -27.3004 -0.876384 16 1 Pose
Z46080221 T14
native IFP available
T14
selection_import_t14
0.795 1.000 0.416 native_similarity final_rank_score -23.0122 -0.789348 10 4 Pose
Z46080221 T16
native IFP available
T16
selection_import_t16
0.782 1.000 0.378 native_similarity final_rank_score -22.5633 -0.860003 14 3 Pose
Z46080221 T18
native IFP available
T18
selection_import_t18
0.758 1.000 0.309 native_similarity final_rank_score -18.8607 -0.711934 13 2 Pose