FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
Reset
2 compounds in matrix 8 best compound-target hits listed 8 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T03T08T10T12T18T19T22
Z45452525 0.903 0.837 6 0.83 0.87 0.86 0.90 0.74 0.81
Z45452525 0.855 0.839 2 0.85 0.82

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z45452525 T12
native IFP available
T12
selection_import_t12
0.903 1.000 0.722 native_similarity final_rank_score -28.7628 -0.841732 18 9 Pose
Z45452525 T08
native IFP available
T08
selection_import_t08
0.873 1.000 0.637 native_similarity final_rank_score -31.6549 -1.00379 18 3 Pose
Z45452525 T10
native IFP available
T10
selection_import_t10
0.859 1.000 0.599 native_similarity final_rank_score -23.41 -0.813551 16 8 Pose
Z45452525 T01
native IFP available
T01
selection_import_t01
0.855 1.000 0.584 native_similarity final_rank_score -24.9162 -0.802139 18 2 Pose
Z45452525 T03
native IFP available
T03
selection_import_t03
0.827 1.000 0.507 native_similarity final_rank_score -25.4018 -0.835379 20 2 Pose
Z45452525 T18
native IFP available
T18
selection_import_t18
0.824 1.000 0.497 native_similarity final_rank_score -21.5029 -0.653259 12 1 Pose
Z45452525 T22
native IFP available
T22
selection_import_t22
0.814 1.000 0.468 native_similarity final_rank_score -30.8756 -0.989254 22 8 Pose
Z45452525 T19
native IFP available
T19
selection_import_t19
0.745 1.000 0.270 native_similarity final_rank_score -33.4383 -1.05214 23 5 Pose